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Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.

Background: During these 2 decades — , many therapeutic strategies have been developed in the field of heart transplant HTx to improve post-HTx outcomes. In the present study, consecutive HTx adults between and were retrospectively reviewed to evaluate the influences of a therapeutic modification on post HTx outcomes.

The overall cumulative survival rate at 10 and 20 years post-HTx was There were no significant differences in survival rate or exercise tolerance after HTx between extracorporeal and implantable continuous flow-LVAD.

Post-HTx patient survival in patients, irrespective of the donor risk factors such as donor age, low LVEF, history of cardiac arrest, was equivalent across cohorts, while longer TIT and higher inotrope dosage prior to procurement surgery were significant risk factors for survival. In 21 patients given everolimus EVL due to renal dysfunction, serum creatinine significantly decreased 1 year after initiation.

In 22 patients given EVL due to transplant coronary vasculopathy TCAV , maximum intimal thickness significantly decreased 3 years after initiation. Conclusions: The analysis of a year single-center experience with HTx in Japan shows encouraging improved results when several therapeutic modifications were made; for example, proactive use of donor hearts declined by other centers and the use of EVL in patients with renal dysfunction and TCAV.

Background: Right ventricular RV volumetric and functional assessments are both crucial for the management of patients with hypoplastic left heart syndrome HLHS. Background: Parathyroid hormone PTH has been associated with cardiovascular disorders; however, it is unknown whether plasma PTH concentrations are associated with atrial fibrillation AF in patients with chronic kidney disease CKD. Associations between plasma intact PTH concentration quartiles Q1—Q4, from lowest to highest and the presence of AF were analyzed using logistic regression.

Conclusions: Higher plasma intact PTH concentrations were significantly and incrementally associated with an increased prevalence of AF in non-dialysis-dependent CKD patients. However, the existing mouse pulmonary hypertension PH models do not reflect these features enough. The relationship between inflammation and hypoxia is still unclear. Hemodynamic and histological analyses showed that the PriHx mice showed a more severe phenotype of PH than pristane or hypoxia alone.

Pristane administration exacerbated lung fibrosis and elevated the expression of fibrosis-related genes. Released: September 25, Volume 83 Issue 10 Pages Released: October 25, Volume 85 Issue 11 Pages Japanese Circulation Journal. Request a Permission. Already have an account? Login in here. Circulation Journal. Follow Circulation Research at:.

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